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KMID : 1188320140080030254
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Gut and Liver
2014 Volume.8 No. 3 p.254 ~ p.264
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Recent Chemotherapy Reduces the Maximum-Standardized Uptake Value of 18F-Fluoro-Deoxyglucose Positron Emission Tomography in Colorectal Cancer
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Lee Min-Jong
Yeum Tae-Sung
Kim Ji-Won
Oh So-Hee
Lee Shin-Ae
Moon Hong-Ran
Choi Young-Hoon
Han Yoo-Min
Choi Ji-Min
Jang Ae-Ra
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Abstract
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Background/Aims:The aim of this study was to evaluate the influence of recent chemotherapy on the patterns of the maximum-standardized uptake value (M-SUV) and sensitivity of 18F-fluoro-deoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in colorectal cancer.
Methods:We retrospectively analyzed the FDG-PET/CT of 509 patients who underwent surgery for colorectal cancer. Subgroup analysis was performed according to chemotherapy status; 401 patients were not treated with chemotherapy and 108 patients were treated with chemotherapy within 6 months prior to surgery. Pathologic analysis of the surgical specimen was used as the gold standard.
Results:The M-SUV was significantly lower in patients treated with chemotherapy than in those not treated with chemotherapy in pathologically confirmed same stages of disease. The difference in the sensitivity of the M-SUV according to chemotherapy status was greatest using a cutoff M-SUV value of 6.4 (p<0.001). The longest diameter of the primary tumor was the most important factor that correlated with M-SUV of the primary tumor irrespective of the chemotherapy effect (p<0.001). The M-SUV of the primary tumor was not an independent predictor of lymph node metastasis in colorectal cancer.
Conclusions:The results indicate that the M-SUV of FDG-PET/CT should be interpreted in the context of concurrent chemotherapy.
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KEYWORD
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Drug therapy, FDG-PET/CT, Colorectal neoplasms
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